TSC22D3

TSC22 domain family protein 3 is a protein that in humans is encoded by the TSC22D3 gene.^[5][6]

TSC22D3
Identifiers
Aliases	TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP, TSC22 domain family member 3
External IDs	OMIM: 300506; MGI: 1196284; HomoloGene: 104035; GeneCards: TSC22D3; OMA:TSC22D3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 107,713,221 bp[1] End 107,777,342 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 139,440,277 bp[2] End 139,501,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung gastric mucosa popliteal artery tibial arteries tibial nerve left coronary artery blood left uterine tube Achilles tendon olfactory bulb Top expressed in muscle of thigh umbilical cord medial head of gastrocnemius muscle right lung lobe stroma of bone marrow left lung lobe temporal muscle triceps brachii muscle ankle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MRF binding protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytosol cytoplasm nucleus Biological process response to osmotic stress ion transmembrane transport regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of skeletal muscle tissue development negative regulation of activation-induced cell death of T cells regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1831 14605 Ensembl ENSG00000157514 ENSMUSG00000031431 UniProt Q99576 Q9Z2S7 RefSeq (mRNA) NM_001015881 NM_004089 NM_198057 NM_001318468 NM_001318470 NM_001077364 NM_010286 RefSeq (protein) NP_001015881 NP_001305397 NP_001305399 NP_004080 NP_932174 NP_001070832 NP_034416 Location (UCSC) Chr X: 107.71 – 107.78 Mb Chr X: 139.44 – 139.5 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. GILZ shows ubiquitous expression across tissues, including thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle.^[7][8] The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.^[6]

Interactions

TSC22D3 has been shown to interact with C-Raf,^[9] NFKB2^[10] and NFKB1.^[10]