TSEN34

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.^[5][6][7]

TSEN34
Identifiers
Aliases	TSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDs	OMIM: 608754; MGI: 1913328; HomoloGene: 44182; GeneCards: TSEN34; OMA:TSEN34 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,189,938 bp[1] End 54,194,536 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,695,862 bp[2] End 3,704,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex gonad mucosa of transverse colon right ovary right uterine tube left ovary Top expressed in mesencephalon neural tube yolk sac epiblast placenta rhombencephalon ventricular zone stomach lip heart More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA-intron endonuclease activity lyase activity nucleic acid binding nuclease activity Cellular component nucleolus nucleus tRNA-intron endonuclease complex nucleoplasm Biological process mRNA processing tRNA-type intron splice site recognition and cleavage RNA phosphodiester bond hydrolysis, endonucleolytic tRNA splicing, via endonucleolytic cleavage and ligation RNA phosphodiester bond hydrolysis tRNA processing nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79042 66078 Ensembl ENSG00000278622 ENSG00000274129 ENSG00000274796 ENSG00000278712 ENSG00000275165 ENSG00000278605 ENSG00000273896 ENSG00000274078 ENSG00000274672 ENSG00000170892 ENSMUSG00000035585 UniProt Q9BSV6 Q8BMZ5 RefSeq (mRNA) NM_001077446 NM_001282332 NM_001282333 NM_024075 NM_001386740 NM_001164204 NM_001164205 NM_024168 RefSeq (protein) NP_001070914 NP_001269261 NP_001269262 NP_076980 NP_001157676 NP_001157677 NP_077130 Location (UCSC) Chr 19: 54.19 – 54.19 Mb Chr 7: 3.7 – 3.7 Mb PubMed search [3] [4]
Wikidata
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tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[7]

Interactions

TSEN34 has been shown to interact with TSEN2.^[6]