TSPAN2

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.^[5][6][7]

TSPAN2
Identifiers
Aliases	TSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDs	OMIM: 613133; MGI: 1917997; HomoloGene: 21169; GeneCards: TSPAN2; OMA:TSPAN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 115,048,011 bp[1] End 115,089,503 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 102,641,845 bp[2] End 102,708,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus muscle layer of sigmoid colon popliteal artery tibial arteries right coronary artery tail of epididymis Descending thoracic aorta ascending aorta islet of Langerhans gastric mucosa Top expressed in ventral tegmental area lateral geniculate nucleus globus pallidus deep cerebellar nuclei left lung lobe lateral hypothalamus right lung medial geniculate nucleus right lung lobe central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane myelin sheath plasma membrane integral component of plasma membrane membrane Biological process astrocyte development myelination cell surface receptor signaling pathway axon development brain development oligodendrocyte differentiation inflammatory response microglia development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10100 70747 Ensembl ENSG00000134198 ENSMUSG00000027858 UniProt O60636 Q922J6 RefSeq (mRNA) NM_001308315 NM_001308316 NM_005725 NM_001243132 NM_027533 RefSeq (protein) NP_001295244 NP_001295245 NP_005716 NP_001230061 NP_081809 Location (UCSC) Chr 1: 115.05 – 115.09 Mb Chr 3: 102.64 – 102.71 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.^[7]