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TSPAN8

Protein-coding gene in humans From Wikipedia, the free encyclopedia

TSPAN8
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Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[5][6]

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Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[6]

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Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.[7]

References

Further reading

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