TSSC1

Protein TSSC1 is a protein that in humans is encoded by the TSSC1 gene.^[5][6][7]

EIPR1
Identifiers
Aliases	EIPR1, TSSC1, tumor suppressing subtransferable candidate 1, EIPR-1, EARP complex and GARP complex interacting protein 1
External IDs	OMIM: 608998; MGI: 1289332; HomoloGene: 2481; GeneCards: EIPR1; OMA:EIPR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.3 Start 3,188,925 bp[1] End 3,377,830 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A2|12 11.26 cM Start 28,801,802 bp[2] End 28,919,864 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex anterior pituitary nucleus accumbens anterior cingulate cortex right frontal lobe putamen Brodmann area 9 caudate nucleus oocyte olfactory zone of nasal mucosa Top expressed in dentate gyrus of hippocampal formation granule cell yolk sac superior frontal gyrus morula embryo blood right kidney embryo primary visual cortex neural tube More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 7260 380752 Ensembl ENSG00000032389 ENSMUSG00000036613 UniProt Q53HC9 Q8K0G5 RefSeq (mRNA) NM_003310 NM_001330530 NM_001330531 NM_201357 NM_001379229 NM_001379230 RefSeq (protein) NP_001317459 NP_001317460 NP_003301 NP_958745 NP_001366158 NP_001366159 NP_001390093 NP_001390094 Location (UCSC) Chr 2: 3.19 – 3.38 Mb Chr 12: 28.8 – 28.92 Mb PubMed search [3] [4]
Wikidata
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Function

This gene has been reported^[8] as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene may reside on chromosome 2 rather than chromosome 11.^[7]