TTC37

TTC37 (Tetratricopeptide repeat domain 37) is a protein which in humans is encoded by gene TTC37, located on chromosome 5. ^[5][6]

TTC37
Identifiers
Aliases	TTC37, KIAA0372, Ski3, THES, tetratricopeptide repeat domain 37
External IDs	OMIM: 614589; MGI: 2679923; HomoloGene: 40966; GeneCards: TTC37; OMA:TTC37 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 95,461,755 bp[1] End 95,554,977 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 76,246,853 bp[2] End 76,338,435 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon stromal cell of endometrium skin of thigh right hemisphere of cerebellum skin of hip germinal epithelium epithelium of colon biceps brachii body of pancreas skin of abdomen Top expressed in zygote secondary oocyte hand primary oocyte cumulus cell spermatid otolith organ utricle lacrimal gland internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Ski complex nucleoplasm nucleus cytoplasm cytosol Biological process exonucleolytic catabolism of deadenylated mRNA RNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9652 218343 Ensembl ENSG00000198677 ENSMUSG00000033991 UniProt Q6PGP7 F8VPK0 RefSeq (mRNA) NM_014639 NM_001081352 RefSeq (protein) NP_055454 NP_001074821 Location (UCSC) Chr 5: 95.46 – 95.55 Mb Chr 13: 76.25 – 76.34 Mb PubMed search [3] [4]
Wikidata
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Structure

The length of the polypeptide chain is 1,564 amino acids, and the molecular weight is 175,486 Da.^[6] TTC37 contains six tetratricopeptide repeat domains.^[6]

Function

TTC37 is a component of the Ski complex which is involved in exosome mediated RNA decay.^[7]

Subcellular distribution

It is localized in the cytoplasmatic space and the cell nucleus.^[5]

Clinical significance

Mutation in the TTC37 gene are associated with tricho-hepato-enteric syndrome.^[8][9]