TTLL1

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.^[5][6][7]

TTLL1
Identifiers
Aliases	TTLL1, C22orf7, HS323M22B, tubulin tyrosine ligase like 1, TTL family tubulin polyglutamylase complex subunit L1, TPGS3
External IDs	OMIM: 608955; MGI: 2443047; HomoloGene: 8174; GeneCards: TTLL1; OMA:TTLL1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 43,039,516 bp[1] End 43,089,419 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,367,970 bp[2] End 83,395,094 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence bronchial epithelial cell ventricular zone testicle mucosa of paranasal sinus prefrontal cortex frontal pole right uterine tube oocyte Top expressed in myocardium of ventricle interventricular septum right ventricle Rostral migratory stream cardiac muscles facial motor nucleus anterior horn of spinal cord dorsomedial hypothalamic nucleus median eminence paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity ATP binding tubulin-glutamic acid ligase activity Cellular component cytoplasm microtubule cytoskeleton extracellular region Biological process epithelial cilium movement involved in extracellular fluid movement protein polyglutamylation axoneme assembly sperm axoneme assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25809 319953 Ensembl ENSG00000100271 ENSMUSG00000022442 UniProt O95922 Q91V51 RefSeq (mRNA) NM_001008572 NM_012263 NM_178869 NM_001357953 RefSeq (protein) NP_036395 NP_849200 NP_001344882 Location (UCSC) Chr 22: 43.04 – 43.09 Mb Chr 15: 83.37 – 83.4 Mb PubMed search [3] [4]
Wikidata
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