TUBA1B

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.^[5][6][7]

TUBA1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E4H, 4TV8, 3RYI, 3JAR, 4TUY, 4TV9, 4YJ2, 3RYH, 3JAK, 3JAS, 4F61, 3UT5, 4O4J, 4YJ3, 4EB6, 4WBN, 3JAW, 4O2A, 3RYF, 3JAL, 4O4H, 4LNU, 3J8Y, 4IIJ, 4O4I, 3RYC, 4O4L, 4O2B, 4I50, 3JAT, 4HNA, 4F6R, 3J8X, 5CA0, 5ITZ, 5JQG, 5IJ0, 5FNV, 5IJ9
Identifiers
Aliases	TUBA1B, K-ALPHA-1, tubulin alpha 1b
External IDs	OMIM: 602530; MGI: 107804; HomoloGene: 134527; GeneCards: TUBA1B; OMA:TUBA1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,127,782 bp[1] End 49,131,397 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,829,306 bp[2] End 98,832,446 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone frontal pole superior frontal gyrus prefrontal cortex Thalamus Brodmann area 10 right frontal lobe dorsolateral prefrontal cortex cingulate gyrus anterior cingulate cortex Top expressed in ventricular zone Hypothalamus tail of embryo Mesencephalon epiblast neural tube genital tubercle dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding structural molecule activity structural constituent of cytoskeleton protein binding GTPase activity double-stranded RNA binding ubiquitin protein ligase binding Cellular component cytoplasm myelin sheath cytoplasmic microtubule microtubule cytoskeleton microtubule cytoskeleton membrane raft Biological process cellular response to interleukin-4 cytoskeleton-dependent intracellular transport cell division microtubule-based process microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10376 22143 Ensembl ENSG00000123416 ENSMUSG00000023004 UniProt P68363 P05213 RefSeq (mRNA) NM_006082 NM_011654 RefSeq (protein) NP_006073 NP_035784 Location (UCSC) Chr 12: 49.13 – 49.13 Mb Chr 15: 98.83 – 98.83 Mb PubMed search [3] [4]
Wikidata
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Interactions

TUBA1B has been shown to interact with PIK3R1.^[8] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.^[9]