TUSC2

Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene.^[5][6][7]

TUSC2
Identifiers
Aliases	TUSC2, C3orf11, FUS1, PAP, PDAP2, tumor suppressor candidate 2, tumor suppressor 2, mitochondrial calcium regulator
External IDs	OMIM: 607052; MGI: 1931086; HomoloGene: 5264; GeneCards: TUSC2; OMA:TUSC2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,320,027 bp[1] End 50,328,251 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 107,440,454 bp[2] End 107,443,311 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 9 pars compacta pars reticulata nucleus accumbens amygdala lateral nuclear group of thalamus Top expressed in right kidney superior frontal gyrus muscle of thigh primary visual cortex dentate gyrus of hippocampal formation granule cell gastrula proximal tubule neural layer of retina cerebellar cortex neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component mitochondrion Biological process regulation of mitochondrial membrane potential cell-cell signaling cell cycle chemokine (C-C motif) ligand 5 production cell population proliferation inflammatory response negative regulation of interleukin-17 production cell maturation neutrophil-mediated killing of gram-negative bacterium regulation of reactive oxygen species metabolic process defense response to Gram-negative bacterium interleukin-15 production positive regulation of interleukin-10 production phagocytosis natural killer cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11334 80385 Ensembl ENSG00000114383 ENSMUSG00000010054 UniProt O75896 Q9WVF8 RefSeq (mRNA) NM_007275 NM_019742 RefSeq (protein) NP_009206 NP_062716 Location (UCSC) Chr 3: 50.32 – 50.33 Mb Chr 9: 107.44 – 107.44 Mb PubMed search [3] [4]
Wikidata
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This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available.^[7]