TWSG1

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.^[5][6] The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.^[7] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.^[8]

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049; MGI: 2137520; HomoloGene: 10774; GeneCards: TWSG1; OMA:TWSG1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.22 Start 9,334,767 bp[1] End 9,402,420 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.1|17 35.26 cM Start 66,228,967 bp[2] End 66,258,221 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula cartilage tissue germinal epithelium caput epididymis corpus epididymis tibia tail of epididymis visceral pleura parietal pleura Descending thoracic aorta Top expressed in cumulus cell tail of embryo ascending aorta aortic valve medullary collecting duct genital tubercle corneal stroma efferent ductule right ventricle molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transforming growth factor beta binding Cellular component extracellular region extracellular space Biological process negative regulation of BMP signaling pathway multicellular organism development mesoderm formation cell differentiation forebrain development camera-type eye development salivary gland morphogenesis BMP signaling pathway ossification negative regulation of osteoblast differentiation tissue development positive regulation of BMP signaling pathway negative regulation of cytokine production transforming growth factor beta receptor signaling pathway positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57045 65960 Ensembl ENSG00000128791 ENSMUSG00000024098 UniProt Q9GZX9 Q9EP52 RefSeq (mRNA) NM_020648 NM_023053 RefSeq (protein) NP_065699 NP_075540 Location (UCSC) Chr 18: 9.33 – 9.4 Mb Chr 17: 66.23 – 66.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse