TXK (gene)

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.^[5][6][7]

TXK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DM0
Identifiers
Aliases	TXK, BTKL, PSCTK5, PTK4, RLK, TKL, TXK tyrosine kinase
External IDs	OMIM: 600058; MGI: 102960; HomoloGene: 2497; GeneCards: TXK; OMA:TXK - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12 Start 48,066,393 bp[1] End 48,134,250 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.2|5 38.44 cM Start 72,853,321 bp[2] End 72,910,120 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood testicle spleen lymph node appendix right uterine tube bone marrow cell right lobe of liver upper lobe of left lung Top expressed in thymus blood lymph node morula pharynx mesenteric lymph nodes spleen subcutaneous adipose tissue granulocyte ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding DNA binding protein kinase activity DNA-binding transcription activator activity, RNA polymerase II-specific kinase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein tyrosine kinase activity signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity Cellular component cytoplasm membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane nucleus Biological process cell differentiation regulation of transcription, DNA-templated adaptive immune response phosphorylation tissue regeneration transmembrane receptor protein tyrosine kinase signaling pathway immune system process regulation of transcription by RNA polymerase II cytokine production positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma production activation of phospholipase C activity transcription, DNA-templated protein phosphorylation regulation of cell population proliferation peptidyl-tyrosine autophosphorylation integrin-mediated signaling pathway protein autophosphorylation regulation of platelet activation T cell receptor signaling pathway positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7294 22165 Ensembl ENSG00000074966 ENSMUSG00000054892 UniProt P42681 P42682 RefSeq (mRNA) NM_003328 NM_001122754 NM_001289494 NM_001289495 NM_013698 RefSeq (protein) NP_003319 NP_001116226 NP_001276423 NP_001276424 NP_038726 Location (UCSC) Chr 4: 48.07 – 48.13 Mb Chr 5: 72.85 – 72.91 Mb PubMed search [3] [4]
Wikidata
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