TXNIP

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^[5][6]

TXNIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GEI, 4GEJ, 4GFX, 4LL1, 4LL4, 4ROF, 4ROJ, 5CQ2, 5DF6, 5DWS, 5DZD
Identifiers
Aliases	TXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1, ARRDC6
External IDs	OMIM: 606599; MGI: 1889549; HomoloGene: 38186; GeneCards: TXNIP; OMA:TXNIP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,992,435 bp[1] End 145,996,579 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 41.93 cM Start 96,465,273 bp[2] End 96,469,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung gastric mucosa cardia pericardium skin of hip renal medulla deltoid muscle canal of the cervix nipple glutes Top expressed in right lung submandibular gland right lung lobe masseter muscle left lung muscle of thigh brown adipose tissue left lung lobe secondary oocyte gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity protein binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol mitochondrial intermembrane space nucleus Biological process cellular response to tumor cell response to estradiol negative regulation of catalytic activity regulation of transcription, DNA-templated protein import into nucleus response to progesterone response to mechanical stimulus negative regulation of transcription by RNA polymerase II response to glucose response to oxidative stress transcription, DNA-templated keratinocyte differentiation response to calcium ion negative regulation of cell division regulation of cell population proliferation positive regulation of apoptotic process cell cycle platelet-derived growth factor receptor signaling pathway response to hydrogen peroxide signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10628 56338 Ensembl ENSG00000265972 ENSMUSG00000038393 UniProt Q9H3M7 Q8BG60 RefSeq (mRNA) NM_006472 NM_001313972 NM_001009935 NM_023719 RefSeq (protein) NP_001300901 NP_006463 NP_001009935 NP_076208 Location (UCSC) Chr 1: 145.99 – 146 Mb Chr 3: 96.47 – 96.47 Mb PubMed search [3] [4]
Wikidata
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Interactions

TXNIP has been shown to interact with Thioredoxin^[7] and ZBTB32.^[8]

Related gene problems

• TAR syndrome
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome