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Tabernanthine

Chemical compound From Wikipedia, the free encyclopedia

Tabernanthine
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Tabernanthine is an alkaloid found in Tabernanthe iboga.[1]

Quick Facts Clinical data, ATC code ...

It has been used in laboratory experiments to study how addiction affects the brain.[2]

Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.[3]

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Pharmacology

It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist.[4][5] Compared to ibogaine, it binds weakly to σ1 and σ2 receptor.[5]

See also

References

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