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Tabernanthine
Chemical compound From Wikipedia, the free encyclopedia
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Tabernanthine is an alkaloid found in Tabernanthe iboga.[1]
It has been used in laboratory experiments to study how addiction affects the brain.[2]
Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.[3]
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Pharmacology
It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist.[4][5] Compared to ibogaine, it binds weakly to σ1 and σ2 receptor.[5]
See also
References
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