Tenascin-R

Tenascin-R is a protein that in humans is encoded by the TNR gene.^[5][6][7]

TNR
Identifiers
Aliases	TNR, TN-R, tenascin R, NEDSTO
External IDs	OMIM: 601995; MGI: 99516; HomoloGene: 124416; GeneCards: TNR; OMA:TNR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 175,315,194 bp[1] End 175,743,616 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H1 Start 159,351,339 bp[2] End 159,759,299 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper entorhinal cortex inferior ganglion of vagus nerve medulla oblongata subthalamic nucleus superior vestibular nucleus ventral tegmental area postcentral gyrus inferior olivary nucleus pars reticulata Top expressed in dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord primary visual cortex superior frontal gyrus ciliary body iris facial motor nucleus neural layer of retina hippocampus proper anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region cell surface membrane raft perineuronal net collagen-containing extracellular matrix extracellular matrix Schaffer collateral - CA1 synapse glutamatergic synapse Biological process negative regulation of neuron projection development positive regulation of synaptic transmission, glutamatergic extracellular matrix organization axon guidance synapse organization positive regulation of transmission of nerve impulse neuron cell-cell adhesion negative regulation of cell-cell adhesion telencephalon cell migration negative regulation of axon extension locomotory exploration behavior long-term potentiation neuromuscular process controlling balance regulation of neurogenesis negative regulation of axon extension involved in regeneration negative regulation of synaptic transmission modulation of chemical synaptic transmission associative learning cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7143 21960 Ensembl ENSG00000116147 ENSMUSG00000015829 UniProt Q92752 Q8BYI9 RefSeq (mRNA) NM_003285 NM_001328635 NM_022312 RefSeq (protein) NP_001315564 NP_003276 NP_003276.3 NP_071707 Location (UCSC) Chr 1: 175.32 – 175.74 Mb Chr 1: 159.35 – 159.76 Mb PubMed search [3] [4]
Wikidata
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Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes 4 genes in mammals: TNC (or hexabrachion), TNX (TNXB), TNW (also known as TNN) and TNR.^[8][9] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]^[7]