Testosterone 17beta-dehydrogenase

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the interconversion of testosterone and androstenedione.^[1]

Testosterone

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

Androstenedione

+ NADPH

 

testosterone 17-beta-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.64
CAS no.	9028-63-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor.^[2][3][4]

Names

The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD⁺ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants

There are two variants of the enzyme, one that uses NADP⁺ as cofactor,^[1] and one that uses NAD⁺ instead.^[5]

NAD⁺

Main article: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.239) uses the cofactor oxidised nicotinamide adenine dinucleotide.

NADP⁺

Main article: Testosterone 17b-dehydrogenase (NADP+)

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.64) uses the cofactor oxidised nicotinamide adenine dinucleotide phosphate.

See also

• Testosterone glucuronide