Tezosentan

Tezosentan is a non-selective ET_A and ET_B receptor antagonist.^[1] It acts as a vasodilator and was designed by Actelion as a therapy for patients with acute heart failure. However, studies showed that tezosentan did not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.^[2]

Tezosentan

Clinical data
ATC code	none
Identifiers
IUPAC name N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide
CAS Number	180384-57-0 Y
PubChem CID	151174
ChemSpider	133242 Y
UNII	64J9J55263
ChEMBL	ChEMBL61780 Y
CompTox Dashboard (EPA)	DTXSID20170956
Chemical and physical data
Formula	C27H27N9O6S
Molar mass	605.63 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c1ncc(cc1)C(C)C)Nc3nc(nc(OCCO)c3Oc2ccccc2OC)c5ccnc(c4n[nH]nn4)c5
InChI InChI=1S/C27H27N9O6S/c1-16(2)18-8-9-22(29-15-18)43(38,39)34-26-23(42-21-7-5-4-6-20(21)40-3)27(41-13-12-37)31-24(30-26)17-10-11-28-19(14-17)25-32-35-36-33-25/h4-11,14-16,37H,12-13H2,1-3H3,(H,30,31,34)(H,32,33,35,36) Y Key:TUYWTLTWNJOZNY-UHFFFAOYSA-N Y
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