Thymidine kinase 1

"TK1" redirects here. For the video game, see Tekken (video game).

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.^[5]

TK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W4R, 1XBT, 2ORV, 2WVJ
Identifiers
Aliases	TK1, TK2, Thymidine kinase 1
External IDs	OMIM: 188300; MGI: 98763; HomoloGene: 37749; GeneCards: TK1; OMA:TK1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 78,174,091 bp[1] End 78,187,233 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 82.96 cM Start 117,706,352 bp[2] End 117,716,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon gonad stromal cell of endometrium mucosa of esophagus ventricular zone bone marrow ganglionic eminence rectum bone marrow cell oral cavity Top expressed in blastocyst fetal liver hematopoietic progenitor cell morula ventricular zone otic vesicle tibiofemoral joint mandibular prominence maxillary prominence dermis otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleoside kinase activity zinc ion binding metal ion binding kinase activity protein binding identical protein binding ATP binding thymidine kinase thymidine kinase activity Cellular component cytoplasm cytosol Biological process DNA biosynthetic process phosphorylation pyrimidine nucleoside salvage nucleobase-containing compound metabolic process protein homotetramerization deoxyribonucleoside monophosphate biosynthetic process DNA metabolic process nucleotide biosynthetic process thymidine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7083 21877 Ensembl ENSG00000167900 ENSMUSG00000025574 UniProt P04183 P04184 RefSeq (mRNA) NM_003258 NM_001346663 NM_001363848 NM_001271729 NM_009387 RefSeq (protein) NP_001333592 NP_003249 NP_001350777 NP_001258658 NP_033413 Location (UCSC) Chr 17: 78.17 – 78.19 Mb Chr 11: 117.71 – 117.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Interactions

Thymidine kinase 1 has been shown to interact with P21.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Thymidine Kinase 1 in Cancer

Elevations in serum TK-1 have been found to correlate with the return of breast and other forms of cancer^[7] TK-1 can be used to detect cancer earlier, determine what stage it is in, and detect recurrence. Thymidine Kinase 1 can be measured based on its enzyme activity^[8] or using immunoassay.^[9]