Thymosin beta-4, Y-chromosomal

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.^[3][4]

TMSB4Y
Identifiers
Aliases	TMSB4Y, TB4Y, thymosin beta 4, Y-linked, thymosin beta 4 Y-linked
External IDs	OMIM: 400017; GeneCards: TMSB4Y; OMA:TMSB4Y - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.221 Start 13,703,899 bp[1] End 13,706,024 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad corpus callosum testicle rectum mucosa of transverse colon Brodmann area 9 ventricular zone prostate ganglionic eminence putamen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding actin monomer binding Cellular component cytoskeleton cytoplasm nucleus cytosol Biological process sequestering of actin monomers regulation of actin polymerization or depolymerization actin filament organization regulation of cell migration osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9087 n/a Ensembl ENSG00000154620 n/a UniProt O14604 n/a RefSeq (mRNA) NM_004202 n/a RefSeq (protein) NP_004193 n/a Location (UCSC) Chr Y: 13.7 – 13.71 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.^[5]

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.^[4]