Thyrotropin-releasing hormone receptor

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.^[5][6]

TRHR
Identifiers
Aliases	TRHR, TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs	OMIM: 188545; MGI: 98824; HomoloGene: 20707; GeneCards: TRHR; OMA:TRHR - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 109,086,585 bp[1] End 109,121,565 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.2|15 16.82 cM Start 44,059,531 bp[2] End 44,099,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Achilles tendon gonad pituitary gland anterior pituitary ventricle of the heart atrium right auricle of heart left ventricle hippocampal formation Top expressed in facial motor nucleus lumbar subsegment of spinal cord anterior amygdaloid area anterior horn of spinal cord motor neuron ventral tegmental area urethra nucleus accumbens dentate gyrus of hippocampal formation granule cell subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity thyrotropin-releasing hormone receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7201 22045 Ensembl ENSG00000174417 ENSMUSG00000038760 UniProt P34981 P21761 RefSeq (mRNA) NM_003301 NM_013696 RefSeq (protein) NP_003292 NP_038724 Location (UCSC) Chr 8: 109.09 – 109.12 Mb Chr 15: 44.06 – 44.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a G_αq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.