Tra (gene)

For the T-cell receptor alpha locus gene, see TRA (gene).

Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.

Transformer
Identifiers
Organism	Drosophila melanogaster
Symbol	tra
Alt. symbols	CG16724; Dmel\CG16724; Dmtra
Entrez	39849
RefSeq (mRNA)	NM_079390.3
RefSeq (Prot)	NP_524114.1
UniProt	P11596
Other data
Chromosome	3L: 16.58 - 16.58 Mb
Search for Structures Swiss-model Domains InterPro

Fruit fly transformer
Identifiers
Symbol	Transformer
Pfam	PF06495
InterPro	IPR010519
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Alternative splicing of dsx pre-mRNA. Tra2 is a transformer protein; the gene is involved in the regulation of sex determination in many insects.^[1]

Transformer-2
Identifiers
Organism	Drosophila melanogaster
Symbol	tra2
UniProt	P19018
Search for Structures Swiss-model Domains InterPro

The transformer protein controls female somatic sexual differentiation.^[2][3] The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.^[1]