Transaldolase 1

Transaldolase 1 is a protein that in humans is encoded by the TALDO1 gene. ^[5]

TALDO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F05
Identifiers
Aliases	TALDO1, TAL, TAL-H, TALDOR, TALH, transaldolase 1
External IDs	OMIM: 602063; MGI: 1274789; HomoloGene: 4916; GeneCards: TALDO1; OMA:TALDO1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 747,415 bp[1] End 765,012 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,972,112 bp[2] End 140,982,881 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone blood gingival epithelium oocyte monocyte bone marrow oral cavity palpebral conjunctiva secondary oocyte granulocyte Top expressed in granulocyte lacrimal gland blood brown adipose tissue endothelial cell of lymphatic vessel conjunctival fornix retinal pigment epithelium tunica adventitia of aorta fetal liver hematopoietic progenitor cell parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity transaldolase activity catalytic activity protein binding monosaccharide binding carbohydrate binding Cellular component cytoplasm cytosol extracellular exosome intracellular membrane-bounded organelle nucleus nucleoplasm Biological process fructose 6-phosphate metabolic process pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch xylulose biosynthetic process glyceraldehyde-3-phosphate metabolic process interleukin-12-mediated signaling pathway carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6888 21351 Ensembl ENSG00000177156 ENSMUSG00000025503 UniProt P37837 Q93092 RefSeq (mRNA) NM_006755 NM_011528 RefSeq (protein) NP_006746 NP_035658 Location (UCSC) Chr 11: 0.75 – 0.77 Mb Chr 7: 140.97 – 140.98 Mb PubMed search [3] [4]
Wikidata
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Function

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].