Transcription factor IIIB 50 kDa subunit

Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.^[5][6][7]

BRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ROD, 4ROE, 4ROC
Identifiers
Aliases	BRF2, BRFU, TFIIIB50, RNA polymerase III transcription initiation factor 50 kDa subunit, RNA polymerase III transcription initiation factor subunit, BRF2 RNA polymerase III transcription initiation factor subunit
External IDs	OMIM: 607013; MGI: 1913903; HomoloGene: 10127; GeneCards: BRF2; OMA:BRF2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 37,843,268 bp[1] End 37,849,861 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,613,392 bp[2] End 27,618,708 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis tibialis anterior muscle deltoid muscle Skeletal muscle tissue of biceps brachii gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle decidua beta cell muscle of thigh Top expressed in primary oocyte spermatid spermatocyte zygote secondary oocyte interventricular septum seminiferous tubule morula hand superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA polymerase III type 3 promoter sequence-specific DNA binding transcription factor binding Cellular component nucleus nucleoplasm transcription factor TFIIIB complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase III cellular response to oxidative stress transcription preinitiation complex assembly DNA-templated transcription, initiation RNA polymerase III preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55290 66653 Ensembl ENSG00000104221 ENSMUSG00000031487 UniProt Q9HAW0 Q3UAW9 RefSeq (mRNA) NM_018310 NM_025686 RefSeq (protein) NP_060780 NP_079962 Location (UCSC) Chr 8: 37.84 – 37.85 Mb Chr 8: 27.61 – 27.62 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.^[7]