Transient neonatal diabetes

Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Transient neonatal diabetes
Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner[1]
Specialty	Pediatrics

Types

Type	OMIM	Gene	Locus	Description
TNDM1	601410	ZFP57, PLAGL1	6p22.1, 6q24.2
TNDM2	610374	ABCC8	11p15.1	Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[2]
TNDM3	610582	KCNJ11	11p15.1

Cause

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).^{[citation needed]}

The form on chromosome 6 can involve imprinting.^[3][4]

Diagnosis

Management

See also

• Permanent neonatal diabetes mellitus