ZFP57

Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.^[5]

ZFP57
Identifiers
Aliases	ZFP57, C6orf40, TNDM1, ZNF698, bA145L22, bA145L22.2, ZFP57 zinc finger protein
External IDs	OMIM: 612192; MGI: 99204; HomoloGene: 7603; GeneCards: ZFP57; OMA:ZFP57 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 29,672,483 bp[1] End 29,681,155 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 Start 37,312,055 bp[2] End 37,321,527 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad C1 segment testicle substantia nigra hippocampus proper putamen amygdala hypothalamus primary visual cortex caudate nucleus Top expressed in secondary oocyte genital tubercle zygote yolk sac primary oocyte neural tube blastocyst ventricular zone tail of embryo ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated regulation of gene expression by genetic imprinting DNA methylation involved in embryo development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346171 22715 Ensembl ENSG00000226858 ENSG00000204644 ENSG00000223858 ENSG00000206510 ENSG00000223852 ENSG00000227858 ENSG00000232099 ENSG00000234669 ENSMUSG00000036036 UniProt Q9NU63 Q8C6P8 RefSeq (mRNA) NM_001109809 NM_001366333 NM_001013745 NM_001168501 NM_001168502 NM_009559 RefSeq (protein) NP_001103279 NP_001353262 NP_001103279.2 NP_001013767 NP_001161973 NP_001161974 Location (UCSC) Chr 6: 29.67 – 29.68 Mb Chr 17: 37.31 – 37.32 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor.^[5]

Clinical significance

Mutations in the ZFP57 gene may be associated with transient neonatal diabetes mellitus.^[6]