Transportin-3

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.^[5][6][7]

TNPO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0O, 4C0P, 4C0Q, 4OL0
Identifiers
Aliases	TNPO3, IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR, transportin 3, LGMDD2
External IDs	OMIM: 610032; MGI: 1196412; HomoloGene: 40848; GeneCards: TNPO3; OMA:TNPO3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 128,954,180 bp[1] End 129,055,173 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A3.3|6 12.36 cM Start 29,540,826 bp[2] End 29,609,886 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tendon of biceps brachii internal globus pallidus pars reticulata pars compacta lateral nuclear group of thalamus external globus pallidus olfactory bulb dorsal motor nucleus of vagus nerve beta cell Top expressed in epiblast maxillary prominence mandibular prominence spermatocyte Ileal epithelium ventricular zone Rostral migratory stream tail of embryo epithelium of lens renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear localization sequence binding protein binding identical protein binding signaling receptor activity nuclear import signal receptor activity Cellular component cytoplasm nuclear membrane intracellular membrane-bounded organelle nucleus Biological process protein transport signal transduction protein import into nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23534 320938 Ensembl ENSG00000064419 ENSMUSG00000012535 UniProt Q9Y5L0 Q6P2B1 RefSeq (mRNA) NM_001191028 NM_012470 NM_177296 NM_001347079 NM_001361290 RefSeq (protein) NP_001177957 NP_036602 NP_001369145 NP_001369146 NP_001369147 NP_001369148 NP_001369149 NP_001369150 NP_001369151 NP_001369152 NP_036602.1 NP_001334008 NP_796270 NP_001348219 Location (UCSC) Chr 7: 128.95 – 129.06 Mb Chr 6: 29.54 – 29.61 Mb PubMed search [3] [4]
Wikidata
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Function

TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.^[5][7]

Clinical significance

The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.^[8]