Tripartite motif containing 34

Tripartite motif containing 34 is a protein that, in humans, is encoded by the TRIM34 gene.^[3]

TRIM34
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EGP
Identifiers
Aliases	TRIM34, IFP1, RNF21, tripartite motif containing 34
External IDs	OMIM: 605684; HomoloGene: 136478; GeneCards: TRIM34; OMA:TRIM34 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,619,764 bp[1] End 5,644,398 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte lymph node blood spleen placenta granulocyte appendix right adrenal gland right adrenal cortex rectum n/a More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding molecular function Cellular component cytoplasm cytosol intracellular anatomical structure Biological process protein trimerization positive regulation of DNA-binding transcription factor activity defense response to virus interferon-gamma-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53840 n/a Ensembl ENSG00000258659 n/a UniProt Q9BYJ4 n/a RefSeq (mRNA) NM_130390 NM_001003827 NM_021616 NM_130389 n/a RefSeq (protein) NP_001003827 NP_067629 NP_569074 n/a Location (UCSC) Chr 11: 5.62 – 5.64 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.