Tubulin beta-4B chain

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.^[5][6] It is thought that this protein could determine which hand is dominant in humans due to variations of the TUBB4B gene, which cause the protein to form microtubules that form cilia which direct fluids asymmetrically during development.^[7]

TUBB4B
Identifiers
Aliases	TUBB4B, Beta2, TUBB2, TUBB2C, tubulin beta 4B class IVb, LCAEOD
External IDs	OMIM: 602660; MGI: 1915472; HomoloGene: 68504; GeneCards: TUBB4B; OMA:TUBB4B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,241,287 bp[1] End 137,243,707 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,112,172 bp[2] End 25,114,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis bronchial epithelial cell right uterine tube spinal ganglia olfactory zone of nasal mucosa pars compacta mucosa of ileum orbitofrontal cortex Brodmann area 46 Top expressed in spermatid testicle spermatocyte primary oocyte secondary oocyte hypothalamus esophagus bone marrow lens epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding unfolded protein binding GTP binding structural constituent of cytoskeleton GTPase activity double-stranded RNA binding MHC class I protein binding Cellular component cytoplasm extracellular vesicle cytosol myelin sheath microtubule cytoskeleton extracellular exosome nucleus extracellular matrix extracellular region microtubule cytoskeleton azurophil granule lumen Biological process G2/M transition of mitotic cell cycle microtubule-based process natural killer cell mediated cytotoxicity cytoskeleton organization neutrophil degranulation ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10383 227613 Ensembl ENSG00000188229 ENSMUSG00000036752 UniProt P68371 P68372 RefSeq (mRNA) NM_006088 NM_146116 RefSeq (protein) NP_006079 NP_666228 Location (UCSC) Chr 9: 137.24 – 137.24 Mb Chr 2: 25.11 – 25.11 Mb PubMed search [3] [4]
Wikidata
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