U2 small nuclear RNA auxiliary factor 1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

U2 small nuclear RNA auxiliary factor 1

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.[3][4][5]

Quick Facts U2AF1, Available structures ...
U2AF1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesU2AF1, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1
External IDsOMIM: 191317; HomoloGene: 134334; GeneCards: U2AF1; OMA:U2AF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001025203
NM_001025204
NM_006758

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 21: 43.09 – 43.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human
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Function

This gene belongs to the splicing factor SR family of genes [citation needed]. U2AF1 is a subunit of the U2 Auxiliary Factor complex alongside a larger subunit, U2AF2. U2AF1 is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes a small (~35 kDa) subunit which plays a critical role in RNA splicing by recognizing and binding to AG nucleotides at the 3’ splice site to facilitate spliceosome assembly.[6] Alternatively spliced transcript variants encoding different isoforms have been identified [citation needed]. Somatic mutations in U2AF1 have been found in a range of human cancers, with a distinctive pattern of these mutations at the zinc fingers implicating a functional role under selection.[7] In lung cancers, these mutations affect alternative splicing of several transcripts, including oncogenic ROS1 fusions.[8] U2af1 conditional deletion in mouse hematopoietic system leads to early lethality suggesting its important for hematopoietic stem cell maintenance and function {https://doi.org/10.1038/s41375-020-01116-x }.

Interactions

U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:

References

Further reading

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