UACA

Not to be confused with Uaçá River.

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.^[5][6][7] Diseases associated with UACA include Graves' Disease.^[8] Among its related pathways are signaling by Rho GTPases and Intrinsic Pathway for Apoptosis. An important paralog of this gene is ANKRD24.^[9]

UACA
Identifiers
Aliases	UACA, NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516; MGI: 1919815; HomoloGene: 74297; GeneCards: UACA; OMA:UACA - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 70,654,554 bp[1] End 70,763,558 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 60,701,824 bp[2] End 60,787,652 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon pancreatic ductal cell sural nerve cardia renal medulla ventral tegmental area pylorus nipple trigeminal ganglion subthalamic nucleus Top expressed in otolith organ ankle utricle muscle of thigh tibialis anterior muscle lumbar spinal ganglion esophagus medial head of gastrocnemius muscle skeletal muscle tissue knee joint More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component extracellular region extracellular exosome cytoskeleton nucleus cytoplasm cytosol Biological process apoptotic signaling pathway regulation of NIK/NF-kappaB signaling biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55075 72565 Ensembl ENSG00000137831 ENSMUSG00000034485 UniProt Q9BZF9 Q8CGB3 RefSeq (mRNA) NM_001008224 NM_018003 NM_028283 NM_001357407 NM_001357408 RefSeq (protein) NP_001008225 NP_060473 NP_082559 NP_001344336 NP_001344337 Location (UCSC) Chr 15: 70.65 – 70.76 Mb Chr 9: 60.7 – 60.79 Mb PubMed search [3] [4]
Wikidata
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