UBAP1

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.^[5]

UBAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGN, 4AE4
Identifiers
Aliases	UBAP1, NAG20, UAP, UBAP, UBAP-1, ubiquitin associated protein 1, SPG80
External IDs	OMIM: 609787; MGI: 2149543; HomoloGene: 9554; GeneCards: UBAP1; OMA:UBAP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,179,005 bp[1] End 34,252,523 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 41,348,996 bp[2] End 41,390,525 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right adrenal cortex left adrenal gland left adrenal cortex muscle of thigh islet of Langerhans ventricular zone ectocervix blood tibial arteries Top expressed in granulocyte ventricular zone muscle of thigh blood tail of embryo duodenum right kidney esophagus neural layer of retina spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin binding protein binding Cellular component cytoplasm cytosol endosome plasma membrane Golgi apparatus ESCRT I complex endosome membrane host cell Biological process protein transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway endosomal transport viral life cycle intracellular transport of virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51271 67123 Ensembl ENSG00000165006 ENSMUSG00000028437 UniProt Q9NZ09 Q8BH48 RefSeq (mRNA) NM_001171201 NM_001171202 NM_001171203 NM_001171204 NM_016525 NM_001290454 NM_023305 NM_001355508 NM_001355509 RefSeq (protein) NP_001164672 NP_001164673 NP_001164674 NP_001164675 NP_057609 NP_001277383 NP_075794 NP_001342437 NP_001342438 Location (UCSC) Chr 9: 34.18 – 34.25 Mb Chr 4: 41.35 – 41.39 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the ubiquitin-associated domain (UBA) family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin-binding domain consisting of a compact three-helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas.^[5] Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia.^[6]