UBE1C

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.^[5][6]

UBA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R4M, 1R4N, 1TT5, 1Y8X, 1YOV, 2LQ7, 2NVU, 3DBH, 3DBL, 3DBR, 3FN1, 3GZN
Identifiers
Aliases	UBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3
External IDs	OMIM: 603172; MGI: 1341217; HomoloGene: 2951; GeneCards: UBA3; OMA:UBA3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 69,054,730 bp[1] End 69,080,408 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D3 Start 97,160,631 bp[2] End 97,182,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva monocyte secondary oocyte epithelium of nasopharynx skin of thigh germinal epithelium gingival epithelium right ventricle skin of hip mucosa of paranasal sinus Top expressed in otic placode saccule medullary collecting duct barrel cortex renal corpuscle otic vesicle primitive streak atrioventricular junction medial ganglionic eminence superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity protein binding protein heterodimerization activity acid-amino acid ligase activity NEDD8 activating enzyme activity ubiquitin-like modifier activating enzyme activity ATP binding identical protein binding NEDD8 transferase activity nuclear receptor binding Cellular component nucleus cytosol cytoplasm protein-containing complex Biological process proteolysis regulation of cell cycle mitotic cell cycle endomitotic cell cycle cell cycle negative regulation of transcription, DNA-templated post-translational protein modification protein neddylation protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9039 22200 Ensembl ENSG00000144744 ENSMUSG00000030061 UniProt Q8TBC4 Q8C878 RefSeq (mRNA) NM_003968 NM_198195 NM_198197 NM_001363861 NM_001111106 NM_001301857 NM_001301858 NM_001301859 NM_011666 RefSeq (protein) NP_003959 NP_937838 NP_001350790 NP_001104576 NP_001288786 NP_001288787 NP_001288788 NP_035796 Location (UCSC) Chr 3: 69.05 – 69.08 Mb Chr 6: 97.16 – 97.18 Mb PubMed search [3] [4]
Wikidata
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E2 binding domain
appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
Identifiers
Symbol	E2_bind
Pfam	PF08825
InterPro	IPR014929
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]

This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.^[7]

Interactions

UBE1C has been shown to interact with NEDD8,^[8] APPBP1^[9] and UBE2M.^[7]