UBE2B

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.^[5][6]

UBE2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JAS, 2Y4W, 2YB6, 2YBF
Identifiers
Aliases	UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
External IDs	OMIM: 179095; MGI: 102944; HomoloGene: 101298; GeneCards: UBE2B; OMA:UBE2B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,371,184 bp[1] End 134,392,108 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 51,876,324 bp[2] End 51,891,589 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle Skeletal muscle tissue of rectus abdominis right lung right auricle of heart biceps brachii body of pancreas Descending thoracic aorta anterior pituitary ganglionic eminence Top expressed in intercostal muscle medial head of gastrocnemius muscle muscle of thigh quadriceps femoris muscle triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle temporal muscle atrioventricular valve arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ubiquitin protein ligase activity ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding Cellular component cytoplasm membrane plasma membrane replication fork HULC complex nucleoplasm XY body chromatin nucleus Biological process chiasma assembly histone H2A ubiquitination negative regulation of cAMP-mediated signaling postreplication repair ubiquitin-dependent protein catabolic process protein K63-linked ubiquitination meiotic telomere clustering positive regulation of reciprocal meiotic recombination protein stabilization protein polyubiquitination negative regulation of apoptotic process in utero embryonic development protein monoubiquitination sperm axoneme assembly cellular response to DNA damage stimulus protein K11-linked ubiquitination histone lysine demethylation protein K48-linked ubiquitination regulation of histone modification spermatogenesis canonical Wnt signaling pathway synaptonemal complex organization response to UV proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination DNA repair protein ubiquitination positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7320 22210 Ensembl ENSG00000119048 ENSMUSG00000020390 UniProt P63146 P63147 RefSeq (mRNA) NM_003337 NM_009458 NM_001362685 NM_001362686 RefSeq (protein) NP_003328 NP_033484 NP_001349614 NP_001349615 Location (UCSC) Chr 5: 134.37 – 134.39 Mb Chr 11: 51.88 – 51.89 Mb PubMed search [3] [4]
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.^[6]

Interactions

UBE2B has been shown to interact with RAD18.^[7][8]