UBE2D2

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.^[5][6]

UBE2D2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UR6, 1W4U, 2CLW, 2ESK, 2ESO, 2ESP, 2ESQ, 3A33, 3JVZ, 3JW0, 3L1Y, 3TGD, 3ZNI, 4A49, 4A4B, 4A4C, 4AUQ, 4DDG, 4LDT, 4V3K, 4V3L, 4WZ3, 5D1L, 5D1K, 5D0M, 5D0K, 5D1M, 5EDV
Identifiers
Aliases	UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
External IDs	OMIM: 602962; MGI: 1930715; HomoloGene: 2506; GeneCards: UBE2D2; OMA:UBE2D2 - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 139,526,431 bp[1] End 139,628,434 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2 Start 35,904,611 bp[2] End 35,942,547 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence right testis left testis right uterine tube gastrocnemius muscle granulocyte sperm rectum tibial arteries Top expressed in Gonadal ridge ventral tegmental area external carotid artery dorsomedial hypothalamic nucleus pineal gland mammillary body paraventricular nucleus of hypothalamus human fetus median eminence dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding Cellular component cytosol ubiquitin ligase complex nucleoplasm extracellular exosome protein-containing complex Biological process ubiquitin-dependent protein catabolic process protein polyubiquitination stimulatory C-type lectin receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway protein K48-linked ubiquitination regulation of transcription from RNA polymerase II promoter in response to hypoxia T cell receptor signaling pathway protein autoubiquitination protein ubiquitination MyD88-independent toll-like receptor signaling pathway protein targeting to peroxisome protein K11-linked ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7322 56550 Ensembl ENSG00000131508 ENSMUSG00000091896 UniProt P62837 P62838 RefSeq (mRNA) NM_003339 NM_181838 NM_019912 RefSeq (protein) NP_003330 NP_862821 NP_064296 Location (UCSC) Chr 5: 139.53 – 139.63 Mb Chr 18: 35.9 – 35.94 Mb PubMed search [3] [4]
Wikidata
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Function

Modifying proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s; ubiquitin-conjugating enzymes, or E2s; and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms.^[6]

Interactions

UBE2D2 has been shown to interact with:

• Baculoviral IAP repeat-containing protein 3,^[7]
• NEDD4,^[8][9]
• PJA1,^[10]
• PJA2,^[10] and
• UBE3A.^[8][9]