UBE2D3

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.^[5][6]

UBE2D3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X23, 2FUH, 3L1Z, 3RPG, 3UGB, 4BVU, 4R8P, 4S3O, 5IFR
Identifiers
Aliases	UBE2D3, E2(17)KB3, UBC4/5, UBCH5C, ubiquitin conjugating enzyme E2 D3
External IDs	OMIM: 602963; MGI: 1913355; HomoloGene: 123914; GeneCards: UBE2D3; OMA:UBE2D3 - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 102,794,383 bp[1] End 102,868,896 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 135,438,149 bp[2] End 135,468,198 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm Achilles tendon monocyte buccal mucosa cell blood cartilage tissue islet of Langerhans appendix right lung Top expressed in genital tubercle seminiferous tubule tail of embryo zygote somite secondary oocyte dermis molar skin of external ear abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin-protein transferase activity Cellular component cytosol endosome membrane plasma membrane nucleoplasm endosome membrane extracellular exosome Biological process positive regulation of protein targeting to mitochondrion protein polyubiquitination negative regulation of transcription by RNA polymerase II protein monoubiquitination BMP signaling pathway cellular response to DNA damage stimulus protein K11-linked ubiquitination TRIF-dependent toll-like receptor signaling pathway protein K48-linked ubiquitination regulation of transcription from RNA polymerase II promoter in response to hypoxia DNA repair protein autoubiquitination apoptotic process protein ubiquitination ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process MyD88-independent toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7323 66105 Ensembl ENSG00000109332 ENSMUSG00000078578 UniProt P61077 P61079 RefSeq (mRNA) NM_001300795 NM_003340 NM_181886 NM_181887 NM_181888 NM_181889 NM_181890 NM_181891 NM_181892 NM_181893 NM_025356 RefSeq (protein) NP_001287724 NP_003331 NP_871615 NP_871616 NP_871617 NP_871618 NP_871619 NP_871620 NP_871621 NP_871622 NP_079632 NP_001343523 NP_001343524 NP_001343525 NP_001343526 NP_001343527 Location (UCSC) Chr 4: 102.79 – 102.87 Mb Chr 3: 135.44 – 135.47 Mb PubMed search [3] [4]
Wikidata
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Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.^[6]

Interactions

UBE2D3 has been shown to interact with NEDD4.^[7][8]