UBE2E1

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.^[5][6]

UBE2E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XR9, 3BZH, 4JJQ
Identifiers
Aliases	UBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDs	OMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.2 Start 23,805,955 bp[1] End 23,891,640 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A1 Start 4,137,837 bp[2] End 4,186,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue oral cavity ventricular zone embryo skin of arm superficial temporal artery bronchial epithelial cell mucosa of paranasal sinus pons lower lobe of lung Top expressed in otic placode otic vesicle saccule mammillary body ventral tegmental area dorsomedial hypothalamic nucleus arcuate nucleus paraventricular nucleus of hypothalamus nasal epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ISG15 transferase activity ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity Cellular component cytosol ubiquitin ligase complex nucleoplasm nucleus Biological process histone monoubiquitination ubiquitin-dependent protein catabolic process protein polyubiquitination protein K48-linked ubiquitination ISG15-protein conjugation anaphase-promoting complex-dependent catabolic process histone H2B ubiquitination protein ubiquitination regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7324 22194 Ensembl ENSG00000170142 ENSMUSG00000021774 UniProt P51965 P52482 RefSeq (mRNA) NM_001202476 NM_003341 NM_182666 NM_009455 RefSeq (protein) NP_001189405 NP_003332 NP_872607 NP_003332.1 NP_033481 Location (UCSC) Chr 3: 23.81 – 23.89 Mb Chr 14: 4.14 – 4.19 Mb PubMed search [3] [4]
Wikidata
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Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]

Interactions

UBE2E1 has been shown to interact with Ataxin 1^[7] and NEDD4.^[8][9]