UBE2L6

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.^[5][6]

UBE2L6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WZV, 1WZW, 2KJH
Identifiers
Aliases	UBE2L6, RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6
External IDs	OMIM: 603890; MGI: 1914500; HomoloGene: 3112; GeneCards: UBE2L6; OMA:UBE2L6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 57,551,656 bp[1] End 57,568,284 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 D Start 84,629,172 bp[2] End 84,640,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte tendon of biceps brachii palpebral conjunctiva ganglionic eminence lymph node spleen appendix gallbladder stromal cell of endometrium Top expressed in blood blastocyst granulocyte fetal liver hematopoietic progenitor cell yolk sac tibiofemoral joint spleen embryo lumbar spinal ganglion duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-like protein transferase activity transferase activity ISG15 transferase activity protein binding ubiquitin-protein transferase activity ubiquitin binding ubiquitin protein ligase binding ubiquitin conjugating enzyme activity Cellular component cytosol nucleoplasm ubiquitin ligase complex Biological process ISG15-protein conjugation translesion synthesis negative regulation of type I interferon production modification-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9246 56791 Ensembl ENSG00000156587 ENSMUSG00000027078 UniProt O14933 Q9QZU9 RefSeq (mRNA) NM_198183 NM_004223 NM_019949 RefSeq (protein) NP_004214 NP_937826 NP_064333 Location (UCSC) Chr 11: 57.55 – 57.57 Mb Chr 2: 84.63 – 84.64 Mb PubMed search [3] [4]
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.

This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]