UBE2N

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.^[5][6]

UBE2N
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J7D, 2C2V, 3HCT, 3HCU, 3VON, 3W31, 4DHI, 4DHJ, 4DHZ, 4IP3, 4NR3, 4NRG, 4NRI, 4ONL, 4ONM, 4ONN, 4ORH, 4TKP, 5AIT, 5AIU, 4WHV
Identifiers
Aliases	UBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
External IDs	OMIM: 603679; MGI: 1934835; HomoloGene: 128406; GeneCards: UBE2N; OMA:UBE2N - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 93,405,673 bp[1] End 93,441,947 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 95,351,007 bp[2] End 95,381,519 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm ganglionic eminence islet of Langerhans ventricular zone right ventricle pons human penis myocardium Top expressed in spermatid spermatocyte ventricular zone tail of embryo esophagus embryo embryo dentate gyrus of hippocampal formation granule cell blastocyst yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ubiquitin protein ligase activity ubiquitin binding protein binding ATP binding ubiquitin protein ligase binding RNA binding ubiquitin-protein transferase activity ubiquitin conjugating enzyme activity Cellular component cytoplasm cytosol UBC13-UEV1A complex ubiquitin ligase complex nucleoplasm extracellular exosome UBC13-MMS2 complex nucleus fibrillar center protein-containing complex Biological process postreplication repair protein K63-linked ubiquitination regulation of DNA repair DNA double-strand break processing positive regulation of DNA repair stimulatory C-type lectin receptor signaling pathway proteolysis cellular response to DNA damage stimulus Fc-epsilon receptor signaling pathway global genome nucleotide-excision repair positive regulation of histone modification positive regulation of ubiquitin-protein transferase activity protein ubiquitination regulation of histone ubiquitination positive regulation of I-kappaB kinase/NF-kappaB signaling T cell receptor signaling pathway double-strand break repair via nonhomologous end joining nucleotide-binding oligomerization domain containing signaling pathway histone ubiquitination DNA repair double-strand break repair via homologous recombination JNK cascade positive regulation of NF-kappaB transcription factor activity ubiquitin-dependent protein catabolic process interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7334 93765 Ensembl ENSG00000177889 ENSMUSG00000074781 UniProt P61088 P61089 RefSeq (mRNA) NM_003348 NM_080560 RefSeq (protein) NP_003339 NP_542127 Location (UCSC) Chr 12: 93.41 – 93.44 Mb Chr 10: 95.35 – 95.38 Mb PubMed search [3] [4]
Wikidata
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Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.^[6]

Interactions

UBE2N has been shown to interact with:

• AURKA,^[7]
• HLTF,^[8]
• TRAF2,^[9]
• TRAF6,^[9] and
• UBE2V1.^[9]