UCHL3

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.^[5][6]

UCHL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCH, 1XD3
Identifiers
Aliases	UCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDs	OMIM: 603090; MGI: 1355274; HomoloGene: 4377; GeneCards: UCHL3; OMA:UCHL3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.2 Start 75,549,480 bp[1] End 75,606,020 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E2.3|14 50.9 cM Start 101,891,403 bp[2] End 101,933,561 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland islet of Langerhans left adrenal cortex mucosa of esophagus rectum skin of leg gastrocnemius muscle skin of abdomen Top expressed in left ventricle interventricular septum spermatid epiblast embryo spermatocyte neural tube esophagus placenta Mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cysteine-type peptidase activity hydrolase activity peptidase activity ubiquitin binding NEDD8-specific protease activity thiol-dependent deubiquitinase Cellular component nucleus intracellular anatomical structure cytoplasm cytosol Biological process protein catabolic process proteolysis ubiquitin-dependent protein catabolic process post-translational protein modification protein deubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7347 50933 Ensembl ENSG00000118939 ENSMUSG00000022111 UniProt P15374 Q9JKB1 RefSeq (mRNA) NM_001270952 NM_006002 NM_016723 RefSeq (protein) NP_001257881 NP_005993 NP_057932 Location (UCSC) Chr 13: 75.55 – 75.61 Mb Chr 14: 101.89 – 101.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.^[7][8]

See also

• Ubiquitin carboxy-terminal hydrolase L1—an enzyme