UCN3

Urocortin-3 is a protein that, in humans, is encoded by the UCN3 gene.^[5][6] It belongs to the corticotropin-releasing hormone family.^[7]

UCN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RMH, 3N93
Identifiers
Aliases	UCN3, SCP, SPC, UCNIII, urocortin 3
External IDs	OMIM: 605901; MGI: 1932970; HomoloGene: 49959; GeneCards: UCN3; OMA:UCN3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,364,966 bp[1] End 5,374,692 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 3,990,688 bp[2] End 3,995,349 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans olfactory zone of nasal mucosa mucosa of transverse colon rectum body of pancreas anterior pituitary gallbladder duodenum sigmoid colon muscle layer of sigmoid colon Top expressed in islet of Langerhans duodenum nucleus of stria terminalis jejunum colon primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor binding corticotropin-releasing hormone receptor 2 binding hormone activity corticotropin-releasing hormone receptor binding Cellular component neuron projection varicosity axon terminus axon extracellular region extracellular space intracellular anatomical structure Biological process digestion response to stress cellular response to nutrient levels positive regulation of insulin secretion response to immobilization stress response to glucose response to starvation cellular response to hypoxia positive regulation of membrane potential response to corticosterone regulation of signaling receptor activity adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114131 83428 Ensembl ENSG00000178473 ENSMUSG00000044988 UniProt Q969E3 Q924A4 RefSeq (mRNA) NM_053049 NM_031250 RefSeq (protein) NP_444277 NP_112540 Location (UCSC) Chr 10: 5.36 – 5.37 Mb Chr 13: 3.99 – 4 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors.

In the brain it may be responsible for the effects of stress on appetite. In humans, it is also expressed by alpha cells and beta cells in the pancreas and is co-released with glucagon and insulin to promote somatostatin release from neighboring delta cells, which provides negative feedback on glucagon and insulin secretion.^[8] In spite of the gene family name similarity, the product of this gene has no sequence similarity to Urotensin-II.^[6]