UGT1A6

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.^[5][6][7]

UGT1A6
Identifiers
Aliases	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F, UDP glucuronosyltransferase family 1 member A6, UGT1.5, hUG-BR1, UGT1.3, UGT-1C, UGT1A, UGT1E, UGT-1A, UGT-1E, UGT1A3, UGT1A1, UGT1A5, UGT1-01, UGT1C, UGT1-05, UGT1-03, UGT1.1, UGT1.6, UGT1-06, UGT-1F
External IDs	OMIM: 606431; MGI: 3580629; HomoloGene: 85959; GeneCards: UGT1A6; OMA:UGT1A6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,691,607 bp[1] End 233,773,300 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 88,030,974 bp[2] End 88,146,725 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver human kidney testicle olfactory zone of nasal mucosa urinary bladder skin of abdomen skin of leg duodenum renal cortex Top expressed in urinary bladder white adipose tissue exocrine gland hepatobiliary system liver kidney tubule proximal tubule lateral recess renal medulla loop of Henle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity protein heterodimerization activity enzyme binding glucuronosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process negative regulation of cellular glucuronidation cellular glucuronidation xenobiotic glucuronidation metabolism negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process xenobiotic metabolic process flavonoid glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54578 394435 Ensembl ENSG00000167165 ENSMUSG00000090145 UniProt P19224 K9J7B2 RefSeq (mRNA) NM_205862 NM_001072 NM_201410 RefSeq (protein) NP_001063 NP_995584 NP_958812 Location (UCSC) Chr 2: 233.69 – 233.77 Mb Chr 1: 88.03 – 88.15 Mb PubMed search [3] [4]
Wikidata
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Function

UDP-glucuronosyltransferase 1-6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.^[7]

This enzyme is also responsible for the inactivation of popular analgesic drugs, such as aspirin and acetaminophen, by glucuronidation. The loss of a functional UGT1A6 gene in certain hypercarnivores, and particularly cats, renders the animals extremely sensitive to the adverse effects of these analgesics.^[8]