UGT2A1

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.^[5][6]

UGT2A1
Identifiers
Aliases	UGT2A1, UDPGT2A1, UDP glucuronosyltransferase family 2 member A1 complex locus
External IDs	OMIM: 604716; MGI: 2149905; HomoloGene: 136808; GeneCards: UGT2A1; OMA:UGT2A1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 69,588,417 bp[1] End 69,653,249 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,607,349 bp[2] End 87,638,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa testicle liver pituitary gland right lobe of liver anterior pituitary sural nerve kidney gonad human kidney Top expressed in respiratory epithelium olfactory epithelium olfactory bulb Cortex of frontal lobe exocrine gland hepatobiliary system liver More reference expression data BioGPS n/a
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane Biological process sensory perception of smell detection of chemical stimulus cellular glucuronidation response to stimulus metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10941 94215 Ensembl ENSG00000173610 ENSMUSG00000106677 UniProt Q9Y4X1 Q80X89 RefSeq (mRNA) NM_001252274 NM_001252275 NM_001301239 NM_006798 NM_001389565 NM_053184 RefSeq (protein) NP_001099147 NP_001288162 NP_001239203 NP_001239204 NP_001288168 NP_006789 NP_444414 Location (UCSC) Chr 4: 69.59 – 69.65 Mb Chr 5: 87.61 – 87.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.^[6] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell associated with COVID-19.^[7]