UGT2B17

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.^[5][6]

UGT2B17
Identifiers
Aliases	UGT2B17, BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDs	OMIM: 601903; MGI: 1919023; HomoloGene: 68144; GeneCards: UGT2B17; OMA:UGT2B17 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 68,537,173 bp[1] End 68,576,413 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,064,497 bp[2] End 87,074,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum mucosa of sigmoid colon duodenum appendix epithelium of colon jejunal mucosa rectum right lobe of liver pancreatic epithelial cell Top expressed in left lobe of liver embryo lumbar subsegment of spinal cord right ventricle tibiofemoral joint sexually immature organism medial head of gastrocnemius muscle lumbar spinal ganglion stria vascularis carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity retinoic acid binding hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane organelle membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process steroid metabolic process metabolism cellular glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7367 71773 Ensembl ENSG00000197888 ENSMUSG00000035836 UniProt O75795 Q8R084 RefSeq (mRNA) NM_001077 NM_152811 RefSeq (protein) NP_001068 NP_690024 Location (UCSC) Chr 4: 68.54 – 68.58 Mb Chr 5: 87.06 – 87.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM]^[6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite^[7]