UHMK1

U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the UHMK1 gene.^[5][6]

UHMK1
Identifiers
Aliases	UHMK1, KIS, KIST, P-CIP2, U2AF homology motif (UHM) kinase 1, U2AF homology motif kinase 1
External IDs	OMIM: 608849; MGI: 1341908; HomoloGene: 7801; GeneCards: UHMK1; OMA:UHMK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,497,251 bp[1] End 162,529,631 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,020,989 bp[2] End 170,042,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum pars compacta spinal ganglia epithelium of nasopharynx pars reticulata superior vestibular nucleus trigeminal ganglion nasal epithelium endothelial cell pancreatic epithelial cell Top expressed in medial vestibular nucleus ventral tegmental area dorsal tegmental nucleus deep cerebellar nuclei pontine nuclei cingulate gyrus supraoptic nucleus habenula CA3 field medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding RNA binding nucleic acid binding ribonucleoprotein complex binding ATP binding poly-pyrimidine tract binding pre-mRNA 3'-splice site binding Cellular component ribonucleoprotein granule axon neuronal ribonucleoprotein granule dendrite cytoplasm nucleus nucleoplasm Golgi apparatus commitment complex nuclear speck U2-type prespliceosome U2AF complex cytoplasm Biological process regulation of protein export from nucleus phosphorylation protein phosphorylation peptidyl-serine phosphorylation protein autophosphorylation neuron projection development positive regulation of translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127933 16589 Ensembl ENSG00000152332 ENSMUSG00000026667 UniProt Q8TAS1 P97343 RefSeq (mRNA) NM_001184763 NM_144624 NM_175866 NM_010633 NM_001360809 RefSeq (protein) NP_001171692 NP_653225 NP_787062 NP_034763 NP_001347738 Location (UCSC) Chr 1: 162.5 – 162.53 Mb Chr 1: 170.02 – 170.04 Mb PubMed search [3] [4]
Wikidata
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Function

UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown function.^[7]

Clinical significance

UHMK1 is highly expressed in the brain and has been genetically implicated in schizophrenia in two genetic studies.^[8][9] Mice with the gene encoding stathmin knocked out, so that they do not express this protein in the brain, show abnormal fear responses. This effect could be developed as an animal model for schizophrenia.^[10] UHMK1 also phosphorylates the CNS proteins myelin basic protein (MBP) and synapsin I so that genetic abnormalities in UHMK1 could contribute to the genetic cause of schizophrenia through several different brain pathways. UHMK1 is also implicated in the progression of many cancers such as gastric,^[11] liver,^[12] colorectal,^[13] cervical^[14] and leukemia.^[15]