ULBP3

UL16 binding protein 3 (ULBP3) is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6.^[3][4] ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[3][4] The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[3][4] It functions as a stress-induced ligand for NKG2D receptor.^[3]

ULBP3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1KCG
Identifiers
Aliases	ULBP3, RAET1N, N2DL-3, NKG2DL3, UL16 binding protein 3
External IDs	OMIM: 605699; HomoloGene: 129737; GeneCards: ULBP3; OMA:ULBP3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 150,061,053 bp[1] End 150,069,121 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic epithelial cell cartilage tissue stromal cell of endometrium gingival epithelium tibia gonad ventricular zone islet of Langerhans retinal pigment epithelium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function natural killer cell lectin-like receptor binding protein binding Cellular component anchored component of membrane anchored component of plasma membrane plasma membrane membrane extracellular space external side of plasma membrane Biological process natural killer cell activation viral process natural killer cell mediated cytotoxicity regulation of immune response immune system process T cell mediated cytotoxicity immune response susceptibility to natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79465 n/a Ensembl ENSG00000131019 n/a UniProt Q9BZM4 n/a RefSeq (mRNA) NM_024518 n/a RefSeq (protein) NP_078794 n/a Location (UCSC) Chr 6: 150.06 – 150.07 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human