UNC5A

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[5]

UNC5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V2A
Identifiers
Aliases	UNC5A, UNC5H1, unc-5 netrin receptor A
External IDs	OMIM: 607869; MGI: 894682; HomoloGene: 41474; GeneCards: UNC5A; OMA:UNC5A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,810,519 bp[1] End 176,880,898 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,097,224 bp[2] End 55,153,831 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 primary visual cortex right hemisphere of cerebellum right frontal lobe prefrontal cortex superior frontal gyrus Brodmann area 9 postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex secondary oocyte superior frontal gyrus lumbar subsegment of spinal cord hippocampus proper humerus transitional epithelium of urinary bladder primary oocyte neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function netrin receptor activity Cellular component intrinsic component of plasma membrane integral component of membrane neuronal cell body membrane membrane raft plasma membrane cell projection neuron projection membrane membrane Biological process multicellular organism development neuron projection development signal transduction anterior/posterior axon guidance axon guidance apoptotic process netrin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90249 107448 Ensembl ENSG00000113763 ENSMUSG00000025876 UniProt Q6ZN44 Q8K1S4 RefSeq (mRNA) NM_133369 NM_153131 NM_001311128 RefSeq (protein) NP_588610 NP_001298057 NP_694771 Location (UCSC) Chr 5: 176.81 – 176.88 Mb Chr 13: 55.1 – 55.15 Mb PubMed search [3] [4]
Wikidata
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UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]^[5]

Interactions

UNC5A has been shown to interact with MAGED1.^[6]