UPF3A

Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene.^[4][5][6]

UPF3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L08
Identifiers
Aliases	UPF3A, HRENT3A, UPF3, UPF3 regulator of nonsense transcripts homolog A (yeast), regulator of nonsense mediated mRNA decay
External IDs	OMIM: 605530; MGI: 1914281; HomoloGene: 23395; GeneCards: UPF3A; OMA:UPF3A - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A1.1 Start 13,835,615 bp[1] End 13,849,193 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in seminiferous tubule otolith organ utricle Paneth cell fossa trigeminal ganglion condyle medullary collecting duct renal corpuscle hair follicle BioGPS More reference expression data
Gene ontology Molecular function protein binding telomeric DNA binding RNA binding nucleic acid binding structural constituent of nuclear pore Cellular component exon-exon junction complex intracellular membrane-bounded organelle nucleus cytoplasm cytosol nucleolus Biological process mRNA transport nuclear-transcribed mRNA catabolic process, nonsense-mediated decay positive regulation of translation nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65110 67031 Ensembl ENSG00000169062 ENSMUSG00000038398 UniProt Q9H1J1 Q3ULJ3 RefSeq (mRNA) NM_023011 NM_080687 NM_025924 RefSeq (protein) NP_075387 NP_542418 NP_001340573 NP_001340574 NP_001340575 NP_001340576 NP_001340577 NP_001340578 NP_001340579 NP_001340580 NP_001340581 NP_080200 Location (UCSC) n/a Chr 8: 13.84 – 13.85 Mb PubMed search [2] [3]
Wikidata
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It complexes with RBM8A to bind specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms exist.^[6]

Interactions

UPF3A interacts with RBM8A,^[7] UPF2^[5][8] and UPF1.^[5][9][10]