UPP1

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.^[5][6][7] It belongs to the uridine phosphorylase enzyme family.

UPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EUE, 3EUF, 3NBQ
Identifiers
Aliases	UPP1, UDRPASE, UP, UPASE, UPP, uridine phosphorylase 1
External IDs	OMIM: 191730; MGI: 1097668; HomoloGene: 2524; GeneCards: UPP1; OMA:UPP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 48,088,628 bp[1] End 48,108,736 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 9,068,103 bp[2] End 9,086,170 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte upper lobe of left lung monocyte gonad blood buccal mucosa cell mucosa of transverse colon right frontal lobe right lung Top expressed in jejunum duodenum conjunctival fornix primary oocyte blastocyst granulocyte left colon corneal stroma mucous cell of stomach endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity catalytic activity pentosyltransferase activity glycosyltransferase activity uridine phosphorylase activity Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process pyrimidine nucleoside salvage pyrimidine nucleotide metabolic process nucleoside metabolic process uridine metabolic process nucleotide catabolic process cellular response to glucose starvation nucleobase-containing compound metabolic process pyrimidine nucleoside catabolic process UMP salvage uridine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7378 22271 Ensembl ENSG00000183696 ENSMUSG00000020407 UniProt Q16831 P52624 RefSeq (mRNA) NM_001287426 NM_001287428 NM_001287429 NM_001287430 NM_003364 NM_181597 NM_001362774 NM_001159401 NM_001159402 NM_009477 RefSeq (protein) NP_001274355 NP_001274357 NP_001274358 NP_001274359 NP_003355 NP_001349703 NP_001152873 NP_001152874 NP_033503 Location (UCSC) Chr 7: 48.09 – 48.11 Mb Chr 11: 9.07 – 9.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

UPP1 has been shown to interact with Vimentin.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".