USP15

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.^[4][5]

USP15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W6V, 3LMN, 3PPA, 3PV1, 3T9L, 4A3O, 4A3P, 5JJW
Identifiers
Aliases	USP15, UNPH-2, UNPH4, ubiquitin specific peptidase 15
External IDs	OMIM: 604731; MGI: 101857; HomoloGene: 101542; GeneCards: USP15; OMA:USP15 - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10|10 D2 Start 122,940,911 bp[1] End 123,032,900 bp[1]
Gene ontology Molecular function ubiquitin modification-dependent histone binding cysteine-type peptidase activity peptidase activity protein binding catalytic activity thiol-dependent deubiquitinase identical protein binding transforming growth factor beta receptor binding cysteine-type endopeptidase activity SMAD binding hydrolase activity Cellular component cytoplasm nucleus cytosol mitochondrion Biological process pathway-restricted SMAD protein phosphorylation ubiquitin-dependent protein catabolic process monoubiquitinated protein deubiquitination BMP signaling pathway proteolysis histone H2B conserved C-terminal lysine deubiquitination transforming growth factor beta receptor signaling pathway protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9958 14479 Ensembl ENSG00000135655 ENSMUSG00000020124 UniProt Q9Y4E8 Q8R5H1 RefSeq (mRNA) NM_001252078 NM_001252079 NM_006313 NM_001301628 NM_027604 RefSeq (protein) NP_001239007 NP_001239008 NP_006304 NP_001338088 NP_001338089 NP_001338090 NP_001338091 NP_001338092 NP_001338093 NP_001338094 NP_001338095 NP_001288557 NP_081880 Location (UCSC) n/a Chr 10: 122.94 – 123.03 Mb PubMed search [2] [3]
Wikidata
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Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).^[5]

See also

• USP1 (MIM 603478).