UXS1

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene.^[5][6]

UXS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B69, 4GLL, 4LK3, 4M55
Identifiers
Aliases	UXS1, SDR6E1, UGD, UDP-glucuronate decarboxylase 1
External IDs	OMIM: 609749; MGI: 1915133; HomoloGene: 41609; GeneCards: UXS1; OMA:UXS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.2 Start 106,093,308 bp[1] End 106,194,301 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 43,746,966 bp[2] End 43,827,800 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte renal medulla cartilage tissue tibia visceral pleura decidua germinal epithelium spinal ganglia trigeminal ganglion stromal cell of endometrium Top expressed in decidua motor neuron Epithelium of choroid plexus primary oocyte fossa condyle endothelial cell of lymphatic vessel cumulus cell secondary oocyte conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity carboxy-lyase activity NAD+ binding lyase activity UDP-glucuronate decarboxylase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome mitochondrion membrane cytoplasm Biological process protein tetramerization UDP-D-xylose biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80146 67883 Ensembl ENSG00000115652 ENSMUSG00000057363 UniProt Q8NBZ7 Q91XL3 RefSeq (mRNA) NM_001253875 NM_001253876 NM_025076 NM_001377504 NM_001377505 NM_001377506 NM_001377507 NM_001377508 NM_001377509 NM_026430 RefSeq (protein) NP_001240804 NP_001240805 NP_079352 NP_001364433 NP_001364434 NP_001364435 NP_001364436 NP_001364437 NP_001364438 NP_080706 NP_001355216 NP_001355217 NP_001355218 Location (UCSC) Chr 2: 106.09 – 106.19 Mb Chr 1: 43.75 – 43.83 Mb PubMed search [3] [4]
Wikidata
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UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans.[supplied by OMIM]^[6]

See also

• Carboxy-lyases
• Golgi apparatus
• Tetrameric protein
• Uridine diphosphate (UDP)