VAMP1

Vesicle-associated membrane protein 1 (VAMP1) is a protein that in humans is encoded by the VAMP1 gene.^[5][6]

VAMP1
Identifiers
Aliases	VAMP1, SPAX1, SYB1, VAMP-1, vesicle associated membrane protein 1, CMS25
External IDs	OMIM: 185880; MGI: 1313276; HomoloGene: 40678; GeneCards: VAMP1; OMA:VAMP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,462,237 bp[1] End 6,470,677 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 59.32 cM Start 125,192,514 bp[2] End 125,222,927 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Brodmann area 23 primary visual cortex superior vestibular nucleus lateral nuclear group of thalamus spinal ganglia endothelial cell middle temporal gyrus dorsal motor nucleus of vagus nerve inferior olivary nucleus Top expressed in pontine nuclei deep cerebellar nuclei medulla oblongata medial vestibular nucleus anterior horn of spinal cord dorsal tegmental nucleus facial motor nucleus inferior colliculi lateral geniculate nucleus superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding syntaxin binding Cellular component synaptic vesicle membrane synapse integral component of membrane mitochondrion tertiary granule membrane azurophil granule membrane cell junction integral component of plasma membrane neuron projection membrane cell surface specific granule membrane mitochondrial outer membrane cytoplasmic vesicle membrane cytoplasmic vesicle cytosol SNARE complex integral component of synaptic vesicle membrane neuromuscular junction presynapse glutamatergic synapse Biological process SNARE complex assembly vesicle fusion vesicle-mediated transport exocytosis synaptic vesicle priming regulation of synaptic vesicle fusion to presynaptic active zone membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6843 22317 Ensembl ENSG00000139190 ENSMUSG00000030337 UniProt P23763 Q62442 RefSeq (mRNA) NM_001297438 NM_014231 NM_016830 NM_199245 NM_001080557 NM_009496 RefSeq (protein) NP_001284367 NP_055046 NP_058439 NP_954740 NP_001074026 NP_033522 Location (UCSC) Chr 12: 6.46 – 6.47 Mb Chr 6: 125.19 – 125.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[6]

Clinical significance

Homozygous mutations in VAMP1 have been identified in a series of children affected with a form of congenital myasthenic syndrome and similar presynaptic features in these patients and the knock-out VAMP1 mouse have been demonstrated.^[7]

VAMP1 expression has been linked to higher survival rates for lung cancer patients.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".